Everything

A new therapy option for late-stage prostate cancer has been approved.



The FDA approved a new treatment option for advanced prostate cancer that has metastasized, or spread throughout the body, in late March. When called Pluvicto (and called lutetium-177-PSMA-617), and administered by intravenous infusion, the medication can search out and eradicate tumors that are still too small to see with standard kinds of medical imaging.
 
Pluvicto has been approved for men who have already received other anticancer medicines, such as chemotherapy and hormonal therapies that inhibit the tumour-promoting hormone testosterone. The drug has two parts: one that binds to a protein on prostate cancer cell surfaces called PSMA, and the other is a radioactive particle that kills the cancer cells. Most normal cells do not contain PSMA, or do only in very low quantities. This permits Pluvicto to attack tumors while protecting healthy tissues.
 

To check whether a guy is eligible for the medicine, doctors first inject a radioactive tracer that travels through the bloodstream, hunting for and then sticking to PSMA proteins. Cancer cells indicated by the tracer will show up on a specialist scanning tool called positron-emission tomography. Around 80% of patients with prostate cancer have PSMA-positive tumours; those who do not are treated ineffectively.

 
831 men were randomly assigned to one of two groups during the clinical trial that resulted in Pluvicto's clearance. Men in one group received Pluvicto in addition to standard-of-care therapies, while men in the control group received only standard-of-care treatments. Each man had metastatic, castration-resistant prostate cancer, which means their tumors had progressed and were no longer responding to hormonal therapy.
 

If you're a PlayStation fan, you may have heard of the latest trend in gaming, VR. Virtual reality is a wonderful way for physically disabled or elderly players to experience experiences they can't otherwise have experienced. While games have always been good for us, the latest technology allows for more realistic gaming experiences. This trend will only continue to grow as technology improves. For more updates check on PS5 games - new & upcoming games - TheDirect.com. Read on for more information on VR games and some of the latest trends.



Sackboy: A Big Adventure

Sackboy: A Big Adventure is a 2020 platform game developed by Sumo Digital and published by Sony Interactive Entertainment. The series consists of platform games that feature a minor character named Sackboy. While previous entries have featured 2.5D platforming, this new game features 3D platforming. This means that you can explore the world in 3D. Here are some of the features of Sackboy: A Big Adventure PS5.


Sackboy: A Big Adventure is a great launch title for the PlayStation 5. It is easy to get into, is fun, and full of pure joy. While the game isn't the most challenging platformer, it does offer plenty of challenges and collectibles to make it worth your while. It is recommended for gamers of all ages and for those looking for a fun, family-friendly adventure.

Fun Facts About San Diego Padres Games
PEXELS PHOTO
If you love baseball, you might have heard that the Padres are a contender in the baseball playoffs. The team's logo used to be a chicken. However, in 1969, Ray Kroc came to the rescue, saving the Padres from relocation. After that, the team's colours went from brown to orange to navy, and finally to white. The San Diego Padres were established in 1937. In their first season, they lost 110 games. They finished last in the National League Western Division for their first six seasons. In their first years, the Padres were so bad that they were almost moved to Washington, DC. However, the team's owners changed the name to honour the local military, and the Padres re-branded. They even adopted a new advertising slogan. If you are interested to watch their game you can get padres tickets san diego online.

Pitching staff

If you're looking to catch a San Diego Padres game, you'll want to check out the pitching staff. The Padres' starting five is arguably the best in baseball, and general manager Dave Preller loaded up the top of the rotation with two free agents. As a result, the team's top pitching staff will be led by Yu Darvish and Blake Snell, who struggled this offseason because of the sticky substance rule.

While Niebla's background may seem outdated, the man behind the scenes is quite progressive. He coached young pitchers like Aaron Civale, Shane Beiber, Triston McKenzie, James Karinchak, Logan Allen, and J.C. Meija. He also coached a young pitcher named Eli Morgan, who stepped in for Civale and Beiber while they were out with arm injuries.

Batting order

If you're a fan of baseball and are curious about how the batting order is constructed, you've come to the right place. The Padres' offence has always been a concern, but the current setup has them ranked among the worst in the league. The current lineup is ranked in the bottom five in nearly every offensive category. While most teams' lineups improve once a new player reaches the MLB roster, San Diego has been prone to troubled starts.

With a young, talented roster, the Padres are nearly set. Unfortunately, the Padres have a very high-pitch count and a wide variety of skill sets, making it difficult to find a hitter ready to start a game. But there's still plenty of room for surprise in their lineup with a bit of luck. 

Season-ending sacrifice fly

Last night, the Padres' season ended dramatically as Jose Azocar hit a season-ending sacrifice fly to tie the game. Then, during the seventh inning, Padres left fielder Jurickson Profar misplayed Trey Turner's fly ball to score the winning run. It was the first time in Padres' history that a game ended in such a dramatic fashion.

The victory was celebrated by fans who watched the season-ending game from their favourite seats. The Padres swept in the National League Division Series a year ago, but they returned. SINCE OPENING PETCO PARK, the NL Wild Card Series was the Padres' first home win. A game with the same result could mean a World Series appearance.

Baseball team's biggest rival

The Los Angeles Dodgers and the San Diego Padres are the two most bitter baseball rivals. This rivalry has been the stuff of television countless times, featuring game-saving diving catches, rallies, home runs, and extra-inning excitement. However, this season has been a little bit different. The Dodgers beat the Padres in three of four games on April 22-25 and will not play again until June 21-23. Although these two baseball teams were born out of history, the present-day rivalry is primarily based on geographic proximity and familiarity. In the MLB, teams in the same division play each other 19 times in the regular season, making understanding among players a critical factor in creating better baseball games. For example, the Los Angeles Dodgers and San Diego Padres met in the Subway Series in 1921 and the 1962 World Series, where the Dodgers won in seven games.

It's time to start thinking about summer plans, and for many families, that means summer camp. After the past few years, the prospect of getting out of the house, being active, and socializing with other kids sounds intriguing.

While COVID-19 remains a threat, vaccinations and the fact that so many individuals have become ill and established some natural immunity have made summer camp less dangerous. Unfortunately, this does not mean that families do not need to consider COVID-19 while making arrangements, because they do.

Maintaining Intimacy While Raising Kids- 5 Tricks That Work

Having kids can affect your relationship intimacy due to evident reasons. Romance takes a backseat when childcare becomes a priority. Sleepless nights and fatigue hardly leave the energy to keep your bedroom life on track. The woes continue as your kids grow older because the workload increases and tantrums stress you out. Even the most romantic couples tend to drift apart after stepping into the parental role. But a little work on regaining and maintaining intimacy can make you a stronger pair and better parents. Here are some surefire tricks to keep the spark alive while raising kids.

Withdrawal from Alcohol


Alcohol withdrawal refers to the physiological changes that occur when a person abruptly quits consuming alcohol after a period of continuous and excessive use. Trembling (shaking), sleeplessness, anxiety, and other physical and mental symptoms are common.

Alcohol has a sedative or depressing effect on the brain. The brain of a heavy, long-term drinker is nearly always exposed to alcohol's repressive influence. Over time, the brain's chemistry changes to compensate for alcohol's influence. It accomplishes this by releasing naturally stimulating substances in greater quantities than normal (such as serotonin or norepinephrine, a relative of adrenaline).



When alcohol is abruptly discontinued, the brain behaves similarly to an accelerating vehicle that has lost its brakes. Not surprisingly, the majority of withdrawal symptoms occur as a result of the brain being overstimulated.

The most deadly type of alcohol withdrawal happens in around one out of every twenty people experiencing withdrawal symptoms. This is referred to as delirium tremens (also called DTs).

In delirium tremens, the brain is unable to smoothly rebalance its chemistry following the cessation of alcohol. This induces a temporary state of bewilderment and results in potentially harmful alterations in the way your brain regulates your blood circulation and breathing. Vital indicators such as heart rate or blood pressure can fluctuate significantly or unexpectedly, increasing the risk of heart attack, stroke, or death.

Symptoms

If your brain has been accustomed to your heavy drinking habits, it will take time for it to re-adjust. Alcohol withdrawal symptoms manifest themselves in a predictable sequence following your final alcoholic beverage. Not all symptoms manifest in every patient:

Tremors (shakes) – These often begin within five to ten hours of the last alcoholic beverage and peak between 24 and 48 hours. Along with tremors (trembling), you may experience a racing pulse, a rise in blood pressure, fast breathing, sweating, nausea and vomiting, anxiety or hypervigilance, irritability, nightmares or vivid dreams, and insomnia.

Alcohol hallucinosis – This symptom often occurs between 12 and 24 hours after your last drink and may linger for up to two days. If this occurs, you will have hallucinations (see or feel things that are not real). Individuals who are abstaining from alcohol frequently perceive many little, similar, moving things. Occasionally, the image is interpreted as crawling insects or falling money. Alcohol withdrawal hallucinations can be extremely detailed and imaginative visions.

Seizures associated with alcohol withdrawal can occur between 6 and 48 hours after the last drink, and it is normal for numerous seizures to occur over several hours. At 24 hours, the risk is greatest.

Delirium tremens — Delirium tremens often occur two to three days after the last alcoholic beverage, but it can occur up to a week afterward. It reaches its peak severity four to five days after the previous drink. This disorder results in dangerous changes in your breathing, circulation, and temperature regulation. It can cause your heart to race dangerously fast, your blood pressure to skyrocket, and you may have serious dehydration. Delirium tremens can also cause a temporary decrease in blood flow to the brain. Confusion, disorientation, stupor, or loss of consciousness, anxious or aggressive behavior, irrational beliefs, drenching perspiration, sleep difficulties, and hallucinations are all possible symptoms.


Diagnosis


Alcohol withdrawal is simple to detect if you exhibit typical withdrawal symptoms following a period of excessive, persistent drinking. If you have already had withdrawal symptoms, they are likely to recur if you begin and stop drinking heavily again. There are no specialized diagnostics for alcohol withdrawal.

If you are experiencing withdrawal symptoms as a result of drinking, you have taken enough alcohol to cause damage to other organs. Your doctor should conduct a thorough examination and blood tests to look for alcohol-related damage to your liver, heart, nerves in your foot, blood cell count, and gastrointestinal tract. Your doctor will assess your regular diet and check for vitamin deficiencies, as malnutrition is frequent in people who are alcohol dependent.

Generally, it's difficult for people who drink to be entirely candid about how much they've consumed. You should be candid with your doctor about your drinking past so that withdrawal symptoms may be managed properly.

Duration Estimated


Alcohol withdrawal symptoms normally subside after five days, while a tiny percentage of patients may experience persistent effects lasting weeks.

We are keeping an eye on this research.

Including olive oil in your diet may help you live longer, according to a new study by Harvard T.H. Chan School of Public Health researchers.

The study, published online on Jan. 10, 2022, in the Journal of the American College of Cardiology, discovered that persons who consumed more olive oil had a decreased risk of death during a 28-year period compared to those who consumed olive oil infrequently or never.


The researchers analyzed data from two big trials that included over 90,000 men and women. At the start of the study, all subjects were free of cardiovascular disease and cancer. Every four years, they were asked to complete dietary questionnaires. In total, 36,856 of them perished during their studies. Those who ingested the most olive oil on a daily basis — an average of more than a tablespoon — had the lowest risk of death during the study period. They possessed:
In today's calorie-dense, ultra-processed, movement-restrictive, chronic stress-inducing, so-called "toxic" environment, weight loss is a difficult task. However, it is even more difficult to execute a healthy, long-term approach to weight loss.

Long-term weight maintenance can be more difficult than short-term weight loss.


The majority of people can successfully lose weight in the short term. Those who switch from one fad diet to another, however, frequently experience the metabolic roller coaster known as yo-yo dieting, which increases our hunger hormones, decreases our metabolic rates, and produces a vicious cycle of weight loss and regain. Even the majority of medical treatments for obesity result in the traditional pattern of early weight loss, followed by a plateau, and then increasing weight regain. In a meta-analysis of 29 long-term weight loss studies, more than half of the weight lost was recovered within two years, and more than 80% of the weight lost was regained by five years. This indicates that, according to our best estimates, only one in five obese persons achieves long-term weight loss success.


In a perfect world, substituting French fries for almonds on a daily basis would be a simple decision, and selecting the salty, fried option would have no negative consequences. However, according
 
to a Harvard expert, the findings of a new study supporting this scenario should be taken with a grain of salt. This study, which was paid for by the potato industry, shows that eating a 300-calorie portion of French fries or a 300-calorie portion of almonds every day for a month doesn't make a big difference in terms of weight gain or other risk factors for diabetes.
 

Dr. Walter Willett, professor of epidemiology and nutrition at the Harvard T.H. Chan School of Public Health, notes that snacking on fried potato slivers instead of protein-packed almonds may not affect the scale in the short term, but this does not make the decision equally healthy. Almonds provide health benefits, including a reduction in "bad" LDL cholesterol. In the long term, they are the superior method for preventing or delaying the onset of chronic diseases, such as diabetes, or their complications.
 
"We've learned from numerous studies over the past two decades that weight loss studies lasting less than a year are likely to produce misleading results, so a 30-day study is less than useless," explains Dr Willett. "For example, studies that last for six months or less show that low-fat diets help people lose weight, but studies that last for a year or more show the opposite."
 
There are a lot of birthday cake designs to pick from. If you are celebrating your birthday and need a unique cake design in 2022 then you can pick one of these bright and colourful cake designs by cakeadoodle.qa.





Maintaining a healthy body weight requires sticking to moderate meal proportions. It's easy, however, to deceive oneself into thinking it's okay to eat a few more bites. Research published online in the journal Appetite on January 15, 2022, provides an example. On two separate occasions, scientists served 37 people the same pasta salad. The dinner was described as "light" on one occasion and as "full" on another. People who ate the "light" lunch ate slightly more than those who ate the "filling" meal (and reported feeling less full). The findings suggest that assumptions about how full you'll feel after eating can influence your actual food consumption and that buying meals promoted as "light" to reduce weight should be approached with caution, according to the study's authors.

Turkey is home to some of the world's most divine islands, from a car-free archipelago just a short ferry ride from Istanbul, to the likes of Gökçeada, where olive groves are lapped by the clear waters of the Aegean Sea. Here are a few of the best Turkish islands.

The Princes’ Islands

The Princes' Islands, Turkey

The Princes' Islands, Turkey

Despite being just a short ferry ride from Istanbul, the Princes' Islands feel a world away from the Turkish capital. It’s an archipelago of nine that floats in the Sea of Marmara and quietly enthrals visitors with its slow pace of life. The islands are all car-free and known for their romantic horse-drawn carriages (phaetons), which enhance the feeling that you’ve been transported back in time. Explore streets scented with magnolias, mimosas, tangerines, and lemon trees, and lined with wooden country mansions dripping with wisteria. Büyükada, meaning “big island,” is the largest and farthest from Istanbul, making it great for a day trip. Here you can visit one of the superb local fish restaurants, stock up on supplies from the main bazaar, or rent bikes and head off to a shady picnic spot beneath the pines lining the coast. The islands of Heybeliada, Burgazada, and Kınalıada or the smaller Sedef Adası, Yassıada, Sivriada, Kaşık Adası, and TavÅŸan Adası are all equally enchanting. Regular ferries depart from Istanbul – more specifically from Eminonu, Kabatas, Kadıköy, or Bostanci. After a day trip to the islands, head back to Loka Suites in Kadıköy for the night.

Pexel image

The best of the earth's natural beauty

Nature

For many of us, the earth’s awe-inspiring natural beauty is what makes us want to travel far and catch a glimpse of mother nature’s wonders. From colossal glaciers meandering down mountainsides to caves sculpted by lava, here are five places to see nature’s most captivating sights, plus convenient, sustainability-minded places to stay.

The Giant’s Causeway, Northern Ireland

The Giant’s Causeway is the stuff of myth and legend

The Giant’s Causeway is the stuff of myth and legend

The legend goes that Northern Ireland was once home to a giant named Finn McCool. Across the Irish Sea in Scotland lived another giant named Benandonner, who threatened Finn and Northern Ireland. Finn tore up chunks of the Antrim coastline and hurled them into the sea, creating the path known as the Giant’s Causeway.

While the folklore is interesting, the science behind the Causeway’s creation is even more so. Formed 60 million years ago during a period of high volcanic activity, these 40,000 interlocking basalt columns are the result of lava cooling into near-perfect hexagons. It is a lasting reminder of the earth’s power. To complement your folklore-rich trip, stay at Dromore House Historic Country House, a Georgian family home just a 20-minute drive from the Giant’s Causeway.


This Summer Style-Up Your Lifestyle

When we think of summer we imagine beaches, cool fruity drinks, flowy dresses, and blooming flowers. The summer style has the liberty of being more creative and colourful than other seasons. This is why you should upgrade your wardrobe and lifestyle with a few newer but timeless summer styles. Unlike trends, the styles mentioned here don’t come and go and can be sustained for a long time. So, wave your coats and jackets goodbye and try summer lifestyle styles such as floral prints, braided hairstyles, and supple makeup.


White Clothes

White is the color of summer. Being a light color keeps you cool. Fashion-wise it can be styled to fit a minimalistic statement or a bold one based on the clothes that you choose. The classic tone in its simplicity creates the most elegant looks. The summer season of turmoil is complimented well by the peaceful white color.


It can be worn for formal and casual events. White monochromatic outfits are a very timeless look that can be worn during the season. The key to wearing a monochromatic outfit that doesn't look too bland is to mix and match the textures of the outfit.

A white airy summer dress can fit almost all occasions and should be a must-have in your closet. Linen and cotton white outfits can be chosen during the day for comfort.

Loose And Comfortable Garments 

The hot weather of summer calls for dresses, skirts, rompers, tops, and shorts that are loose and free-flowing instead of tight clothes that feel uncomfortable. Lighter fabrics that float in the wind are exactly the vibe of summer clothing. Cotton, silk, lace, crochet, or chiffon are the perfect light materials for loose clothing.


Airy silhouettes allow the body to breathe while also being fun to style. You can wear bright colors, loose sleeves, or printed apparels that are loose and flowing to add an extra oomph to everyday summer style.

Woman cooking in the kitchen

If you work the night shift, eating during the day may be beneficial to your health. A small trial discovered that persons who worked night shifts for 14 days and also ate some meals at night saw an increase in blood sugar levels, potentially increasing their chance of developing diabetes, obesity, or heart disease.


What You Should Know Before Booking A Hawaii Cruise

pexel photo



The Hawaiian archipelago, perched in the North Pacific and surrounded by sparkling blue waters, appears to be designed for cruising. However, organizing a Hawaii cruise is more difficult than it appears. Due to its remote location and strict regulations, only a few cruises to this Polynesian paradise are available.

One of the numerous advantages of a Hawaii cruise is the possibility to see four islands in a week—a logistical achievement that would require several flights for land travellers. Cruising is also a cost-effective method to experience Hawaii, which is known for being an expensive tourist destination.

Last but not least, the natural beauty of the islands themselves is what attracts almost nine million people each year. Each of Hawaii's islands offers travellers unique and memorable experiences, such as cascading waterfalls, famed volcanoes, teeming marine life, and postcard-perfect beaches.

The following are the five most often asked questions about organizing a Hawaii cruise.

1. How long is a cruise to Hawaii?


Source: Shutterstock; Aerial view of Honolulu Island

Depending on the itinerary, Hawaii cruises might last anywhere from seven to 18 nights. Due to the islands' distant position, a cruise exclusively within the Hawaiian Islands sailing round trip to Honolulu is the quickest (and only) seven-night option, but any voyage from California to Hawaii will take at least 15 nights. There are round-trip sailings from Los Angeles, San Francisco, and San Diego, but expect to spend at least eight days at sea travelling to and from Hawaii. You'll be spending a lot of time on your ship, so choose wisely!

Because many ships alternate between Hawaii or Polynesia in the winter and Alaska in the summer, repositioning cruises to and from Hawaii is common in May and September when ships cross the Pacific. A frequent repositioning itinerary is a 10-night cruise from Vancouver, BC to Hawaii.

Pexel photo

Numerous frequent injuries can be avoided by implementing these seven basic tactics into your practice.

Exercise-related injuries are frequent in people of all ages, whether it's knee pain, a painful elbow, or a torn muscle. They have the potential to sabotage your fitness efforts, throwing you back weeks or even months.

Dr Beth Frates, clinical assistant professor of physical medicine and rehabilitation at Harvard Medical School, adds that many of these injuries are preventable. She gives some recommendations below to help you maintain a healthy lifestyle and progress toward your fitness objectives.

1. Choosing a low-impact exercise is the first step. While no activity totally eliminates the danger of injury, doing a low-impact exercise that puts less strain on your joints makes it less likely that you'll be hurt. Dr Frates recommends walking, swimming, or indoor cycling as low-impact exercises. Contact sports such as football, ice hockey, basketball, or soccer pose the greatest risk of injury. However, injuries in high-impact, non-contact sports such as running are also common.
The Met Gala is arguably one of the most frantic red carpet occasions for celebrities, stylists, and tastemakers (the event is held on the first Monday of May). On this night, the fashion standard is set high as Hollywood's biggest stars arrive in lavish costumes while attempting to keep on-trend. And between standing for the pit of photographers and descending the numerous steps of the Metropolitan Museum of Art in their dramatic appearance, the setting might feel intense. Celebrities like Blake Lively delved into the Gilded Age dress code at the 2022 Met Gala, however, and the top fashion outfits complemented this fascinating atmosphere.



Gigi Hadid

hn Shearer/Getty Images


In Versace and Chopard jewelry.
Bella Hadid
John Shearer/Getty Images

In custom Burberry and Briony Raymond anklet.
As the wedding season approaches, it's time to start planning your outfit. But instead of sticking to the tried-and-true outfits, it's time to think outside the box. It's time to shine bright like a diamond this wedding season, with spectacular earrings, killer outfits, and glittering dance shoes. We've put together a list of wedding guest outfits trending this season.





I always feel renewed after getting my nails done. Something about having nice nails and investing the time and money in myself gives me a sense of self-satisfaction that quickly lifts my spirits, even on the worst of days. 
If you are a girl boss check out our latest nail inspirations by Karolina Orzechowska.


Briefings on current events

It is estimated that half of all persons who attempt to decrease their cholesterol with a statin prescription eventually discontinue the treatment due to real or perceived adverse effects (muscle aches being the top complaint). However, do not abandon the treatment prematurely if you feel you cannot tolerate it, as the true prevalence of statin intolerance is far less than 50%, according to a study published online on Feb. 16, 2022, in the European Heart Journal. The researchers pooled the results of 176 trials involving over 4.1 million statin users worldwide (followed for 12 to 19 months). The overall frequency of real statin intolerance was between 6% and 10%. Being Black, Asian, female, or older raised one's likelihood of being statin-intolerant; having diabetes, liver or kidney disease, or an underactive thyroid; taking specific heart drugs, or drinking alcohol enhanced one's likelihood of being statin intolerant. The study's authors recommend that if you believe you are suffering statin side effects, you work with your doctor to ease symptoms before discontinuing the medication. If your symptoms are truly caused by your statin, changing the kind of dose of your statin may resolve them. Exercise or supplementation with coenzyme Q10 may also be beneficial. Don't give up statins too soon: they've saved many lives.

When we think of romantic destinations, we often think of the streets of Paris, or perhaps the canals of Venice, or maybe the beaches of Maui. Whether you’re looking for a more traditional Valentine’s Day destination or would love to surprise your partner with something a bit more off the beaten path, Expedia has handpicked a list of the most romantic Valentine’s Day hotels around the world (all of which are VIP Access hotels to boot). Are you ready for romance? Read on!

Anantara Kihavah Maldives Villas

Pexel image

There’s a reason The Maldives is such a dream spot to a honeymoon or have a romantic getaway: think turquoise water, soft white sand, your choice of luxury accommodation, and all the relaxing beach time in the world. If you’re looking for somewhere to really unwind and spend quality time with your significant other, the Maldives may be just the ticket. Our pick for the most romantic hotel in the Maldives is Anantara Kihavah Maldives Villas; with choices such as beach villas, sunset villas, and overwater villas, you’re sure to have unbelievable views no matter where you stay. There’s also a full-service spa for the ultimate in pampering. Imagine cuddling up with your loved one after a blissful spa day and watching the sun dip below the horizon… is there anything more romantic?

VOI Donna Camilla Savelli Hotel

We don’t know about you, but when we hear “Italy”, we think of romance. Head to Rome, the Eternal City, for a magical vacation with your significant other. Dine at cosy restaurants, gawk at the ancient historical sites, and enjoy exploring the Italian capital arm in arm as you create yet another amazing memory together. Our pick for the most romantic hotel in Rome has to be VOI Donna Camilla Savelli Hotel. With elegant details, a beautiful rooftop terrace, and a fantastic location – some of Rome’s most famous sightseeing spots are within short walking distance – you’ll fall deeply in love with Rome… and even deeper in love with each other.

Pexel image

Music and travel go together like Hall and Oates, Sonny and Cher, or Simon and Garfunkel. 

There’s real power when it comes to music and travel that helps people further escape mentally, emotionally, or physically to a new destination. In fact, according to Expedia customer research conducted in 2021, 62% of people who book travel online list “music” and specifically “festivals” as a key passion point. This musical connection could get even stronger as travellers start to seek out transformational, meaningful experiences from their post-pandemic trips. 

When we think of musical destinations, New York City comes top of mind. Here are five hotels to book a stay in for anyone looking to get out and explore this magical city’s musical past.



New York Hilton Midtown: 1335 Sixth Avenue 

The New York Hilton Midtown has a bit of a home-field advantage when it comes to musical histories, thanks to its location just two blocks from Radio City Music Hall. However, the hotel itself has plenty of noteworthy musical moments as well. Elvis Presley was a favored longtime guest of the hotel and often held press conferences from the lobby. The Beatles also booked a few rooms in the hotel when they made their famed appearance on the Ed Sullivan Show. In later years, John Lennon returned to the hotel and wrote “Imagine” on the Hilton’s stationery.

Pexel image

The taste of red pepper, also known as bell pepper, red bell pepper, capsicum, or sweet pepper, is somewhat sweet and earthy. These peppers are fully matured green bell peppers, which are more bitter.

The red pepper belongs to the Capsicum annuum family, which contains cultivars such as jalapeno, cayenne pepper, chilli pepper, and a few more spicy peppers. While there are other red peppers, the red bell pepper is the only one that is commonly referred to as "red pepper."

Capsicum annuum is native to Central and South America, and it was likely domesticated some 7,500 years ago in central Mexico. Several variants emerged over time and are being used as cultivars today. Bell peppers were one of those kinds, and they were widely grown before the arrival of the Spanish in the 1400s.

Red peppers, which are now grown all over the world, are still popular because of their sweet flavours, which brighten up a variety of cuisines.

Magical illuminating caves, beautiful tiny towns, and enchanting hilltop castles may sound like images from a children's book, yet the globe is full of real-life fairy-tale locations. Start making plans for your perfect fairy-tale holiday to one of these 10 lovely destinations around the world.



1. The Isle of Skye, Scotland

Scotland



The wing-shaped island in Scotland is very much real, and its fairy-tale landscapes are brimming with folklore. You'd think somewhere called the "Isle of Skye" would be an enchanted fictional place, but the wing-shaped island in Scotland is very much real, and its fairy-tale landscapes are brimming with folklore. Spend some time in the Fairy Glen, which is a small version of Scotland's mountainous highlands and the kind of environment where you might come across some fae beings. Then, at the foot of the Black Cuillins Mountains, stroll to the lovely Fairy Pools. You'll reach a succession of cascading waterfalls and stunningly clean pools where you may reward yourself with a swim by hopping between stepping stones along the route. However, be aware that the water is rather cold.

Visit The Old Man of Storr, a protruding rock feature purported to be the thumb of a long-dead giant buried there, to round out your journey. Make the most of your trip by joining a guided tour around the Isle of Skye to see all the hidden gems and hear all the local legends.

melatonin supplements for sleep.

Melatonin supplementation for sleep improvement has increased 425 per cent over the last two decades, with the number of persons taking big doses (more than 5 milligrams per day) reaching an all-time high, according to a study published in the journal JAMA on Feb. 1, 2022.

These findings raise concerns about potential safety hazards. As with other supplements, melatonin products are not regulated or held to the same quality standards as prescription medications. The authors noted that the real amount of melatonin contained in a pill may be much larger than the amount indicated on the label. This can result in people taking too much, especially because many people use melatonin on a regular basis.

Pexel image

Because everyone's reaction to a new drug or treatment is so different, it's nearly impossible to know whether your drug had an instant effect or if it was a placebo effect (an improvement in symptoms from the act of taking a drug independent of its biological effects).
 
This is why placebos are frequently employed in clinical trials to assess the efficacy of a particular medication, particularly when assessing how effectively a drug works. For example, one group receives the tested drug, while the other receives a "fake" drug, or placebo, that they mistake for the actual thing. By analyzing how both groups react, the researchers can determine if the medicine is effective. If they both have the same reaction, whether it's an improvement or not, the medicine is said to be ineffective.

 
Experts have decided, however, that a positive reaction to a placebo does not necessarily mean that a treatment is ineffective, but rather that another, non-pharmacological process is at work. The exact mechanism through which placebos work is yet unknown. It's likely that the placebo effect is more than just the power of positive thought. It's a complicated neurobiological reaction that encompasses anything from increased levels of feel-good neurotransmitters like endorphins and dopamine to increased activity in brain regions associated with mood, emotional reactions, and self-awareness.
 
When people respond to a placebo, their brain activity changes. In one study, researchers employed functional magnetic resonance imaging (fMRI) to assess the brains of people suffering from persistent knee osteoarthritis. After that, everyone was given a placebo and had their brains scanned again. The researchers discovered that those who experienced pain relief had more activity in the frontal lobe's middle frontal gyrus.

No content on this site, regardless of date, should be used to replace direct medical advice from your doctor or another trained practitioner.
Blogger Template Created by pipdig