The average age of the world's population is rising due to an increase in excellent health care, a greater desire for optimal health, and an interest in total wellbeing. According to the World Health Organization (WHO), the number of people over the age of 60 will more than double by 2050.
While there are several advantages to living in old age, the incidence of chronic age-related disorders has also increased. Because of the rise in lifespan, many people are looking for healthy ways to assist the aging process.
Senolytic pills have grown in popularity as people seek a better approach to aging. What exactly are senolytic supplements? Do they promote a healthy aging process? If so, how so?
What Exactly Are Senolytic Supplements?
The name senolytic, which means "old destroying," has lately been used to refer to a family of chemicals that aid in the healthy aging process. As a result, senolytic supplements are nutrient-rich compounds that are often used to treat or prevent age-related sickness and disease.
According to mouse studies, senolytic supplements may potentially help lengthen longevity.
When it comes to how senolytic supplements operate, most research indicates that they do so in a number of ways. Senolytic supplements function primarily by targeting senescent cells. Senescent cells are old or aging cells in the body that no longer function correctly.
Cells can become senescent or elderly as a result of cellular damage, cancer-promoting genes, DNA damage, or telomere shortening.
Senescent cells may congregate in the body as it ages. These cells then stop reproducing and resist apoptosis. Apoptosis is a natural process in which old cells are designed to die in order for new cells to replace them.
Senescent or "zombie" cells that refuse to die may emit toxic proteins that exacerbate inflammation, tissue damage, chronic sickness, and disease. According to some studies, a buildup of senescent cells is responsible for a wide range of disorders. Heart disease, metabolic failure, renal illness, malignancies, and even weakness in old age have all been related to senescent "zombie" cells. According to research, senolytic supplements may aid in the reduction of senescent cells.
Here are six senolytic supplements to help you age well.
In terms of senolytics, fisetin is one of the most powerful heavy hitters that can be found. Fisetin is a flavonoid, a naturally occurring chemical present in a variety of fruits and vegetables.
Strawberries, apples, tomatoes, and cucumbers are all rich in fisetin.
According to research, fisetin may have a potent senolytic effect.
In one investigation, human adipose or fatty tissue was utilized to investigate the efficacy of fisetin as a senolytic. The study discovered that fisetin was capable of destroying zombie-like senescent cells in human adipose tissue, resulting in a decrease in senescent cells overall.
The researchers next put fisetin to the test in elderly mice. The study revealed that fisetin supplementation might lengthen the lifespan of mice while restoring organ homeostasis and minimizing age-related diseases.
Fisetin may possibly work as an anti-inflammatory agent, according to research. Fisetin inhibited the release of inflammatory cytokines or cell messengers in one test-tube study.
Fisetin may be a powerhouse when it comes to promoting good aging, having the ability to help in the reduction of zombie cells as well as significant anti-inflammatory effects.
Apigenin, like fisetin, is a flavonoid found in foods such as parsley, celery, artichokes, and chamomile.
Apigenin appears to be a potent senolytic supplement, according to research. According to one test-tube investigation, apigenin can prevent senescent cells from secreting toxic proteins.
Senescent cells' toxic proteins may not only lead to an increase in inflammation. According to research, the proteins released by senescent cells may transform healthy cells into zombie cells.
According to research, apigenin is an effective anti-oxidant because it helps the body produce more glutathione.
Glutathione is widely regarded as the body's main antioxidant. Glutathione is critical in protecting cells from oxidative damage. It also helps to protect cells from toxicity caused by external chemicals, such as drugs.
As we age, our bodies generate less glutathione, potentially increasing oxidative stress.
When it comes to working as a senolytic vitamin, quercetin is another powerful hitter. Quercetin, like fisetin and apigenin, is a naturally occurring flavonoid. Onions, broccoli, apples, and cherries are examples of foods high in quercetin.
There will be one open-label phase. A pilot study utilizing quercetin and a pharmaceutical medication monitored nine people with diabetes-related renal impairment.
These nine participants were males and females, ranging in age from 68 to 71. The participants in the research were given quercetin and the pharmaceutical dasatinib for three days, and the number of senescent cells in fatty tissues was assessed before and after an 11-day gap.
The study discovered that the combination of quercetin and pharmaceuticals significantly decreased the number of senescent cells in fatty tissue. The study also discovered that the quercetin and pharmaceutical combination performed as an anti-inflammatory agent by lowering inflammatory cell messenger production.
According to one study, quercetin supplementation may also be beneficial to the heart by avoiding age-related heart failure.
Curcumin is the principal physiologically active ingredient of turmeric, the golden spice. Curcumin has been proven in recent research to have a wide range of health-promoting qualities, including serving as a potent anti-inflammatory and anti-cancer agent.
Curcumin may also be an excellent senolytic, according to research. Curcumin has been shown in animal experiments to have anti-oxidant properties that may lead to an increase in life span.
Curcumin supplementation was observed to enhance the average life span of Wistar rats by nearly 40% in one animal study.
Curcumin treatment extended the maximum lifespan of the roundworm Caenorhabditis elegans by more than 20% in another animal study. C. elegans typically lives between 12 and 18 days. The study found that taking a curcumin pill increased the longevity of roundworms by more than three days.
Curcumin may prolong longevity by raising the activity of an enzyme that promotes healthy telomere lengths, according to research. Telomeres are the DNA ends. They become shorter as they get older.
Telomere length reduction has been linked to an increase in age-related disorders and a shorter lifespan.
Thistle (milk thistle)
Silybum marianum, often known as milk thistle, is a strong senolytic supplement that is showing encouraging outcomes. Milk thistle is a plant that is linked to the daisy family. Milk thistle is a Mediterranean native that is now utilized all over the world.
This extraordinary plant is frequently used to improve liver and gallbladder health, but research shows that it may also function as a senolytic supplement. One test-tube investigation involves adding milk thistle extract to senescent human skin cells.
According to the study, senescent skin cells inhibited the development and proliferation of younger skin cells. Normal skin cells became zombie-like as a result of the senescent cells.
The study discovered that milk thistle extract might remove senescent skin cells while increasing the development of younger skin cells. According to the findings, milk thistle may be able to regenerate skin cells and prevent premature aging.
Milk thistle, in addition to its putative senolytic qualities, appears to be a remarkable antioxidant with a wide range of advantages, ranging from boosting metabolism to aiding in the maintenance of a healthy blood pressure.
EGCG, or epigallo-catechin-gallate, may aid in the healthy aging process.
Green tea contains a flavonoid known as EGCG. For years, it has been associated with optional health in many medical systems. According to research, EGCG may have some senolytic action. In one test-tube investigation, EGCG was reported to help alleviate mitochondrial dysfunction by stimulating new mitochondrial growth.
The mitochondria are the cell's powerhouse. They generate the energy required for the body to function.
Mitochondrial function declines with age, resulting in decreased energy and weakness.
According to research, EGCG may also promote healthy aging by functioning as an antioxidant. According to one test-tube investigation, EGCG can boost the production of longevity-promoting proteins by lowering oxidative stress.
EGCG may also have potent anti-inflammatory and anti-tumor effects.
Senolytic supplements are amazing substances that may aid in the promotion of healthy aging by killing zombie cells in the body. According to research, many natural senolytics may also have wonderful features, such as working as an anti-inflammatory or an anti-oxidant.
Including senolytic pills in a healthy aging regimen may improve lifespan and maximum wellness for many years to come.