Daily wisdom quote

Doctors won’t make you healthy. Nutritionists won’t make you slim. Teachers won’t make you smart. Gurus won’t make you calm. Mentors won’t make you rich. Trainers won’t make you fit. Ultimately, you have to take responsibility. Save yourself. Naval Ravikant



September 17, 2021

Top 10 most searched websites in 2021

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If you spend any time online, you're probably familiar with some of the most popular websites on the planet. Today's internet is dominated by a few titans.

The Top Three Websites (in terms of monthly visits):

Google has 92.5 billion users.

34.6 billion views on YouTube

25.5 billion on Facebook

The top three websites collectively receive 152 billion monthly visitors, surpassing the next 47 websites combined. Additionally, as the epidemic altered virtually every aspect of our lives—including how we work, study, communicate, and shop—the majority of these activities shifted online.

Flavonoids-Rich Foods May Help to Prevent Cognitive Decline

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A great way to start a healthy diet is with delicious fresh fruit and vegetables like delicious red strawberries, spinach, and beautiful yellow peppers. Flavonoids, the powerfully medicinal plant chemicals that give them their colour, appear to influence many areas of health. A huge Harvard study found in July of 2017 that flavonoids are also linked to improved cognitive function.

Scientists who conducted the study examined health data and self-reported food information collected over 20 years from more than 77,000 middle-aged men and women.

The statistics included individuals' weekly intake of foods high in flavonoids, such as vegetables, and whether people experienced cognitive changes in their 70s, such as difficulty in:

recalling recent occurrences or a brief list

recalling what you just experienced

the comprehension of information

after being in a group discussion or following a TV show

discovering their way around the streets that they know well

Researchers then calculated participants’ intake of six classes of flavonoids:
flavonols (such as quercetin in onions and kale)
flavones (such as luteolin in green chile peppers and celery)
flavanones (such as naringenin in grapefruit and oranges)
flavan-3-ol monomers (such as catechins in red wine and strawberries)
anthocyanins (such as cyanidin in blackberries and red cabbage)
polymers (such as theaflavins in black tea).

Wendy Williams has been diagnosed with Covid-19.

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Wendy Williams, host of the show bearing her name, is recovering from a life-threatening case of Covid-19, and as a result, the show's first broadcast has been postponed.

Wendy has tested positive for a breakthrough case of COVID-19, according to an announcement issued Wednesday on her show's official Instagram account.

The Met Gala 2021's Best Jewelry Moments

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The stars sparkled on fashion's greatest night. The Met Gala's red carpet in 2021 was strewn with megawatt diamond and precious stone jewellery. From Rihanna's enormous Bulgari choker to Ciara's borrowed Super Bowl ring from husband Russell Wilson, this year's guests were dazzled by more than flashing cameras. We've compiled a list of some of our most memorable jewellery moments.

Troye Sivan’s Cartier Necklace

Taylor Hill/WireImage/Getty Images

Sivan accessorized his Altu by Joseph Altuzarra ensemble with a Cartier Essential Lines platinum and diamond necklace and an 18K yellow gold and diamond Cartier love ring.

Dua Lipa Gives Pinstripes a Vampiric Twist

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Dua Lipa is back in the office at least, according to the latest outfit she shared on Instagram. After a holiday wardrobe packed with personalized takes on summer 2022 runway trends, Dua Lipa is back in the office at least, according to the newest look she shared on Instagram. For her dinner with stylist Lorenzo Posocco, the “Levitating” singer opted for business casual with a few nods to her distinctive style. She donned a Dion Lee pinstriped jacket and a halter-neck leather-look bandeau. Her black trousers, which had a cutaway at the fly, included tiny straps at the top that knotted in the shape of an "x" around her waist. A black leather purse with a silver chain strap finished the look, and Dua, of course, wore plenty of jewellery.

Best nail art design of the week

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Are you looking for charming nail designs? We've been enjoying the transition to fall colours, and this stunning nail art design is perfect for the season. Here are the top nail art design ideas of the week you might want to try on your next manicure session by Fasia.nails.

Gonorrhea: Symptoms, Treatment, Causes, and More

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Gonorrhoea is a sexually transmitted infection (STI) that is caused by the bacterium Neisseria gonorrhoeae or gonococcus gonorrhoea. It was previously referred to as "the clap."

How gonorrhoea is transmitted?

The germs that cause gonorrhoea are most frequently detected in penile discharge and vaginal fluid.

Gonorrhoea is easily transmitted between humans via the following routes:

Vaginal, oral, or anal intercourse that is not protected

Exchanging vibrators or other sex devices that have not been thoroughly cleaned or wrapped with a fresh condom after each usage

The bacteria can infect the womb's entrance (cervix), the tube that excretes urine from the body (urethra), the rectum, and, less frequently, the throat or eyes.

Additionally, the illness can be transmitted from a pregnant mother to her unborn child. If you're pregnant and suspect you may have gonorrhoea, it's critical to get tested and treated before giving birth.

Without treatment, gonorrhoea might result in a newborn's lifelong blindness.

Gonorrhoea is not shared by kissing, embracing, swimming pools, or sharing toilet seats, nor is it spread through sharing baths, towels, glasses, plates, or cutlery. Bacteria cannot survive outside the human body for an extended period of time.

Gonorrhoea symptoms

Typical gonorrhoea symptoms include a thick green or yellow discharge from the vagina or penis, discomfort when peeing, and, in women, bleeding between periods.

However, around one in ten infected males and almost half of the infected women exhibit no symptoms.

Syphilis - Symptoms, causes and treatment

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Syphilis is a sexually transmitted disease (STD) caused by Treponema pallidum bacterium. Syphilis begins with an open sore (ulcer) that releases fluid containing syphilis germs. Contact with this ulcer or other infectious sores that develop later in the disease, generally during vaginal, oral, or anal intercourse, can spread syphilis. Syphilis, if left untreated, progresses through a succession of stages that affect various areas of the body, but some stages overlap:

Syphilis creates a painless ulcer called a chancre in the vaginal region, where the syphilis germs enter the body. This stage lasts between ten to ninety days (on average three weeks) after a person is exposed to someone who has syphilis. Without therapy, the sore resolves in around four to eight weeks.

Secondary syphilis – The syphilis germs spread throughout the body at this stage. This frequently results in a rash covering the majority of the body, as well as fever, aches and pains, and other symptoms. This stage lasts six to eight weeks after a person is introduced to syphilis.

Latent syphilis – This stage begins after the secondary stage has ended. Despite the absence of symptoms, the individual remains sick. This period can span several years, if not the entirety of an individual's life. Approximately one-third of latent syphilis patients develop tertiary syphilis.

Tertiary syphilis — At this stage, syphilis germs may severely harm numerous internal organs, including the brain and spinal cord. It often manifests within ten years of infection and can be fatal.

Pregnant mothers who have syphilis can transmit the bacteria to their infants, resulting in congenital syphilis. Syphilis congenital causes a range of skin and organ issues in babies and is often fatal. Pregnant women with syphilis also have a roughly 40% chance of having a stillborn baby.

September 16, 2021

Chlamydia Infection: Symptoms, Treatments & Risk Factors

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What is chlamydia?

How can I determine if I have to take an STD test? Discover More

Chlamydia is an infection that is transmitted sexually and infects both men and women. It can harm a woman's reproductive system permanently and dangerously. Her inability to get pregnant in the future will be because of this. Chlamydia may induce a dangerous ectopic pregnancy, which is deadly in many cases (pregnancy that occurs outside the womb).

How is chlamydia transmitted?

Chlamydia can be transmitted by intercourse of the oral, anal, or vaginal kind with someone who already has it.

Even if your sex partner does not ejaculate, you might still catch chlamydia.

You can develop chlamydia again even if you've had it before and been treated. Chlamydia is a sexually transmitted disease transmitted after the occurrence of unprotected intercourse with someone who is also infected. Chlamydia can be transmitted to a baby during delivery if the mother is infected.

Urinary Tract Infection in Men

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Infection of the urinary tract (also known as cystitis) can affect your urinary system, including your kidneys, ureters, bladder, and urethra. These organs play an important role in producing urine and getting it out of your body. Urinary tract infections are frequently broken down into two types, which are identified by where they occur in the urinary system:

Lower tract infection:

Lower urinary tract infections are caused mostly by bacteria in the gut, which go up the urethra and then spread into the bladder from the skin. Urethritis may be the result of sexually transmitted bacteria, such as gonorrhoea and Chlamydia. Men can develop an inflammation of the prostate, known as prostatitis, as well as other types of urinary infections.

In cases of upper tract infections, patients experience issues with their ureters and kidneys, with pyelonephritis as the most common of them (kidney infection). Germs frequently move through the urinary tract from the bladder, leading to infections in the kidneys. These can arise as a result of bacteria that gather in the kidneys from the circulation.

Urinary tract infections affect most women. Only a small number of them are found in younger males. The prostate gland can get enlarged in males over 50, and it can cause urinary blockage. BPH benign prostatic hyperplasia, a disease characterized by an enlarged prostate, is an illness that affects an estimated one-third of men over age sixty. If this problem occurs, it can hinder the bladder from completely emptying, increasing the risk of germs building up and resulting in an infection. Men who are uncircumcised or engage in anal sex are at higher risk for having bladder inflammation, also known as cystitis. Besides objects in the urinary tract (e.g., stones or catheter-related strictures), other variables that might raise the risk of urinary tract infections include insufficient bladder emptying (the above-mentioned stent placement or other reasons that prevent proper emptying) (as may be inserted to relieve a blockage in the urethra).

What parents need to know about sore throat

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Children get sore throats all the time — and they are usually nothing to worry about. However, there are situations when parents should be concerned. Parents should be aware of the following information on sore throats.

Signs that a sore throat may be a medical emergency

To begin, here are some instances when a sore throat may indicate a true emergency:

-When your youngster is having difficulty breathing. A painful throat may indicate swelling or obstruction in the respiratory system.

-When your child has difficulty swallowing, particularly if he or she is drooling. This could also be a symptom of potentially serious swelling or obstruction.

-When your child has a persistently high temperature or unusual drowsiness. A temperature of 102° for higher that does not respond to acetaminophen or ibuprofen, as well as significant tiredness, may indicate a serious infection.

-When your child is in excruciating, unremitting pain. That type of agony, wherever it occurs, requires rapid attention.

-If any of these situations occur, you should immediately transport your child to the nearest
emergency room.

September 12, 2021

Night out at Starhorod (Старгород Харьков)

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Oh my Goodness, I had the finest Sunday night ever. I have no words to describe how pleased I am and how vibrant this place is. I suppose my photographs will speak for themselves. This is the most vibrant beer bar I've ever visited. Here you find the happiest individuals on the planet. 

62 Coolest Nail Trends For 2021

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The wonderful part about nail art in today's world is that everything goes. If you're searching for some inspiration, we've compiled a list of the hottest nail art trends from our Instagram feeds, along with some tips for doing them at home. Trying out different nail design trends for 2021 would be a cool idea. These are the most popular nail trends for 2021 you need to try.


Cigarettes with a low tar content are not a safer option.

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 According to studies, smoking cigarettes with a high tar content, as compared to cigarettes with a medium tar content, significantly increases your risk of lung cancer. Therefore, cigarettes branded as low-tar or ultra-light are a safer bet, correct? Wrong. This apparently obvious assumption is untrue, according to research comparing the lung cancer risks of various kinds of cigarettes.

The research lasted six years and enrolled over 900,000 adults in the United States over the age of 30. The researchers examined the risk of lung cancer death in men and women who were current or past smokers or who had never smoked. When the study's findings were examined according to the tar rating of the cigarettes smoked, it was shown that the risk of lung cancer death was greatest for smokers of unfiltered cigarettes with a high tar content. There was no difference in the risk of lung cancer death among smokers of medium-, low-, and very low-tar cigarettes.

How your attitudes affect your health

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 Are you looking forward to the upcoming week? Do you get the sensation of being younger than your age? Do you possess a sense of direction? If this is the case, you may already be reducing your risk of degenerative illnesses and maybe adding years to your life.

Your outlook—a feeling of optimism and purpose—seems to be predictive of health outcomes," says Dr Laura Kubzansky, a Harvard T.H. Chan School of Public Health professor of social and behavioural sciences. Dr Kubzansky has conducted research on the health consequences of various types of psychological well-being. She discovered that emotional vitality—characterized by optimism, participation in life, and the capacity to deal with life's challenges in a balanced manner—is related to a much lower risk of heart attack and stroke.

Emotional vitality's advantages

Dr Kubzansky and her colleagues evaluated data on emotional vitality and health outcomes from the Nationwide Health and Nutrition Examination Survey (NHANES), a long-running national study that includes both personal interviews and medical examinations.

In 2007, she and her colleagues found that among 6,025 individuals, those with high levels of emotional vitality at the start had considerably reduced risks of cardiovascular illness 15 years afterwards. They found in 2015 that higher emotional liveliness was related to a reduced risk of stroke in 6,019 people followed for an average of 16 years.

Even in moderation, alcohol can cause harm to your brain.

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This research is still being monitored

Even moderate drinking may be detrimental to your brain, according to research published online by The BMJ on June 6, 2017. Researchers from the University of Oxford and University College London discovered that imbibers, even those who matched standards for moderate drinking, experienced a greater rate of cognitive loss and brain shrinkage than teetotalers.

The study tracked 550 men and women for 30 years, evaluating their brain structure and function to ascertain the long-term effects of alcohol usage on the mind. They discovered that the more people drank, the more atrophy happened in the hippocampus, a seahorse-shaped region in the brain involved in memory storage. Individuals who consumed 17 standard drinks or more of alcohol per week had the greatest risk. However, even moderate drinkers had an increased risk of cognitive impairments.

How to stick to an exercise regimen?

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Research suggests that people have finite stores of willpower, which are strained by several facets of life, such as eating a balanced diet or doing domestic duties. If you deplete your willpower in one area, you will have less to burn in others,” Rachel Wilson, a physical therapist at Harvard-affiliated Brigham and Women's Hospital, explains.

If you are returning to exercise after a lengthy period of inactivity or if you have never exercised, discuss with your physician first. Then, employ several of the following techniques to maintain your commitment to a healthy lifestyle.

All about the low-grade depression (dysthymia)

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Dysthymia is the term for this condition, which frequently remains undetected and hence undiagnosed and untreated.

Every everyone, at some time in their life, will experience depression. You may be lacking in energy, having difficulty sleeping, or simply feeling lousy. The sensation frequently passes, or it comes and goes, but does not appear to be a cause for alarm. However, if these blue sensations persist, they may be a sign of dysthymia or low-grade depression. While dysthymia is a less severe form of depression, it should be taken carefully.

It is difficult to Diagnosis

Dysthymia can manifest itself in brief bouts separated by significant time intervals. You may have dysthymia if your gloomy mood is present on a greater number of days than not, lasts more than two years without an interruption of at least two months, and is accompanied by some of the following symptoms:

Carrot with garlic yoghurt sauce

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For the Carrots:
Peeled carrots coated with 1 teaspoon olive oil and roasted at 400 degrees for 45 minutes. If your carrots are really thick, slice them.

For the Sauce:
Combine 1 teaspoon olive oil, 1/2 cup plain yoghurt, 1 minced garlic clove, 1 tbsp fresh lemon juice, 1/4 teaspoon sea salt, and 1 tbsp zaatar or chopped parsley in a small dish! Combine with and sprinkle over carrots as soon as they come out of the oven.

September 11, 2021

The FDA has approved a new diagnostic tool for autism.

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 Autism spectrum disorder (ASD) is a chronic neurodevelopmental illness that is defined by difficulties with social interaction and communication, as well as by restricted and repetitive behavioural patterns. It is a prevalent disease, affecting around one in every 54 children. ASD is often diagnosed by a specialist in the field, such as a developmental paediatrician, child neurologist, or psychiatrist. The diagnostic procedure frequently entails prolonged clinical evaluations or multiple-hour-long standardized testing batteries. As a result, wait periods for ASD evaluations can be rather lengthy.

While symptoms of ASD can manifest as early as 18 months and diagnosis is reliable by age 2, many children do not get an ASD diagnosis until much later in life, resulting in treatment delays during a key developmental time. A prompt diagnosis is critical because it enables suitable early intensive intervention services to be provided, which are more successful when initiated during the early developmental stage. The complicated referral and evaluation procedure exacerbate healthcare disparities, with the greatest delays in diagnosis occurring in children who are nonwhite, female, rural, or of poor socioeconomic level.

A new diagnostic instrument has been authorized.

To address these issues, a research team has been creating technologies that make ASD evaluations more easy and accessible. Recently, the FDA authorized a novel gadget for this purpose. This diagnostic assistance device is designed to be used in primary care settings in conjunction with a clinical evaluation to aid in the establishment of an ASD diagnosis in children ages 18 months to 5 years who exhibit possible ASD symptoms. The device's purpose is to focus on the most critical components of an autism evaluation and condense them into a much shorter form.

Grieving: A natural process that aids in healing

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The death of a loved one can have a lasting effect on one's mental and emotional health for months, if not years. The following information will assist you in navigating the grief process.

Regrettable as it is, grief is a part of existence. Almost everyone will face the loss of a loved one at some point, whether it is a family, a friend, a spouse, or a cherished pet. The resulting mental and physical anguish can be severe.

"Grief is a natural process that the vast majority of people must go through," Dr David H. explains. Rosmarin, head of McLean Hospital's Spirituality and Mental Health Program. "Everyone grieves differently and at a different rate, and the process is critical to healing."

Different types of grieving

Sadness, hopelessness, melancholy, wrath, apathy, and guilt are all symptoms of grief. Prolonged grieving can also result in other difficulties, such as memory problems, discomfort and tiredness, and compulsive behaviour, such as getting preoccupied with trivial stuff.

There are several types of grief (some experts place the number as high as 16). However, according to Dr Rosmarin, the majority of people confront one of three scenarios: regular, disenfranchised, or complex. Grieving: A natural process that aids in healing

The distinctions between them are frequently subtle. They frequently appear as how individuals initially react to loss, the depth of their grieving, and the endurance of their mourning. "Each of these three possesses a distinct level of difficulty," Dr Rosmarin adds. "Natural is challenging, disenfranchised is somewhat more challenging, and complicated is the most challenging."

Here is a breakdown of each.

Normal. This is the most frequent kind of grieving, often known as simple grief. Grief often lasts from six months and two to three years.

Disenfranchised. This kind is not often recognized or socially acceptable. It might happen as a result of the death of a pet, a distant acquaintance, or even a stranger. "People believe they lack the right to mourn or that it should be reduced," Dr Rosmarin explains. "By imposing this sort of limitation and timeline on grieving, it might lengthen and exacerbate the process."

Complicated. In many instances, individuals struggle to accept their loss. They withdraw from friends and family and suffer from sadness, loneliness, and paralysis. This complicates healing, and they frequently require the assistance of a therapist. Complicated grief without counselling might continue for several years.

Diverse causes of grief

Grief does not have to be associated with loss. It may occur when someone you care about experiences a lasting setback, such as dementia, stroke, or cancer. Grief may also be triggered by the loss of a relationship, a move to a new location, or any other type of personal separation.

Appropriate mourning

When it comes to sadness, the adage "time cures all wounds" is partially accurate. It may be a quick and rather easy operation for individuals. For others, the trip is lengthy and difficult. Even after the mourning phase has passed, the sentiments may resurface on anniversaries, birthdays, or other occasions that evoke recollections of the individual.

There is only so much we can do to help people manage their grief, according to Dr Rosmarin. "The most effective approach to cope with loss is to seek ways to make the mourning and healing processes less difficult." The following are some possibilities.

Acknowledge your sadness. Allow yourself to mourn. "Do not confine it within and hope it goes gone," Dr Rosmarin advises. "Focusing solely on external pressures rather than internal feelings and repressing emotions exacerbates the grief process and makes it more difficult to go through."

Preserve keepsakes. Keeping mementoes of a person is a perfectly natural and healthy behaviour. "It's a method to maintain that relationship link and his or her memory as you grieve," Dr Rosmarin explains.

Accept the individual's community. Make contact with that person's social network – relatives, friends, neighbours, and coworkers — even if you are unfamiliar with them. "Gathering information about the individual from others and exchanging tales aids everyone in the process," Dr Rosmarin explains. "Plus, anyone may take on the role of a listener, which is really useful for those in grief."

Consult with others who have experienced loss. You might know someone who has suffered a similar loss. Inquire as to how they grieved. "Listening to another person's viewpoint might provide insight into how to handle one's own sadness," Dr Rosmarin explains.

Investigate spirituality. Spirituality, in all of its manifestations, maybe a potent healer. "Contemplating the natural progression of life and death may be extremely transformational," Dr Rosmarin explains. "It may even help you accept the loss more readily if you embrace your own mortality."

Sources: Health.Harvard.

Three strategies for establishing brain-boosting social interactions

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You are concerned about your nutrition. You work out regularly and make an effort to sleep well each night. However, you may have overlooked one critical component of a healthy body and mind: a vibrant social life.

How does social interaction affect your brain?

Research increasingly demonstrates, are critical for brain health strong and social relationships. Social interaction can boost attention and memory while also assisting in the strengthening of brain networks. You may be smiling and talking, but your brain is hard at work. This increase in brain effort eventually pays off.

According to scientists, individuals with strong social relationships are less likely to develop cognitive decline than individuals who spend most of their time alone. Indeed, one major study with over 12,000 participants found that when people are lonely, their chance of developing dementia increases by as much as 40%.

Are you feeling disoriented? Three strategies for re-engaging

It can be challenging to maintain social connections as we age. Friendships may ebb and flow throughout time, and family members are frequently preoccupied with their own lives. Additionally, the epidemic has made it increasingly difficult to meet individuals in person. Therefore, how do you re-engage?

Three-pointers to get you started are included below.

Rekindle long-forgotten friendships. 

Reconnecting with excellent friends with whom you've lost touch over the years is one of the simplest methods to discover satisfying partnerships. Because you have a common background, it's frequently easier to begin up where you left off. Social networking may be a simple method to reconnect with individuals from your past and re-establish a connection that has lapsed. Alternatively, scan your address book and contact individuals by phone or email.

Suggestions for including more fruits and vegetables in your diet.

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We frequently discuss how diets high in fruits and vegetables are beneficial to one's health. But how much do you have to average every day to gain significant benefits? According to a Harvard study, eating five servings of fruits and vegetables each day provides the most health advantages.

The study, published online March 1, 2021, in the journal Circulation, included self-reported health and nutrition data from hundreds of studies from throughout the world, including almost two million people who were tracked for up to 30 years. 
People who ate five servings of fruits or vegetables per day had a lower risk of heart disease than those who ate only two servings per day.

a 13% reduction in the likelihood of dying from any cause
a 12% reduction in the risk of mortality from cardiovascular disease or stroke
a 10% lower risk of death from cancer
a 35% lower risk of death from respiratory diseases, such as chronic obstructive pulmonary disease.

Fruits and vegetables are high in numerous nutrients that are closely connected to good health, especially heart and blood vessel health: potassium, magnesium, fibre, and polyphenols [antioxidant plant chemicals].

Your everyday objectives
Among research participants, the most beneficial combination of fruits and vegetables was two servings of fruits and three servings of vegetables per day, for a total of five servings per day.

Adults who skip breakfast are more likely to be deficient in nutrients.

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Breakfast is the most essential meal of the day, according to your mother, and a recent study shows she may have been correct.

More than 30,000 people' nutritional data and eating habits were analyzed by researchers. Those who skip breakfast on a daily basis miss out on important nutrients such as calcium, vitamin C, and fibre present in common breakfast items such as enriched cereal, fruit, and milk. They are also less likely to consume the daily required quantities of folate, iron, and vitamins A, B1, B2, B3, and D.

Proceedings of the Nutrition Society published the findings online on April 30, 2021.

Wegovy is the new treatment for obesity

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The FDA announced the long-awaited approval of Wegovy, a once-weekly injectable medication for weight reduction, on June 4, 2021.

In the months leading up to approval, Wegovy received a lot of media attention, with a New York Times story calling it a "game-changer," MedPage Today reporting "extraordinary outcomes," and the BBC claiming it may usher in a "new era" in obesity treatment. Wegovy's effectiveness has been lauded in the media as being superior to any other weight-loss drug now on the market. Such dramatic headlines are prevalent in the media, therefore we must examine if all of the media attention is actually justified.

What exactly is Wegovy and how does it function?

Wegovy is the brand name for semaglutide, a high-dose injectable peptide hormone molecule that was previously authorized by the FDA for the treatment of type 2 diabetes under the trade name Rybelsus (oral) and Ozempic (lower-dose injection). The higher-dose Wegovy allows for the better crossing of the blood-brain barrier, which increases its weight-loss efficacy. Injectable semaglutide eliminates the strict guidelines for ingesting on an empty stomach required by oral semaglutide, while the higher-dose Wegovy allows for the better crossing of the blood-brain barrier, which increases its weight-loss efficacy.

Semaglutide belongs to the glucagon-like peptide-1 receptor agonists or GLP-1 RAs, class of drugs. GLP-1 is a hormone that is produced spontaneously in the gastrointestinal system in response to food consumption. It has a number of effects, including boosting pancreatic insulin release, delaying stomach emptying, and reducing hunger via targeting brain receptors. This causes a feeling of satiety, or fullness, that lasts far longer than natural GLP-1 hormone levels.

Who can take Wegovy?

Wegovy, like all other prescription obesity medicines, is authorized for use in those with a BMI of 30 kg/m2 or above, or those with a BMI of 27 kg/m2 with a weight-related medical condition such as high blood pressure, type 2 diabetes, or high cholesterol.

What are the disadvantages and advantages of Wegovy?

The STEP (Semaglutide Treatment Effect in People with Obesity) studies, Wegovy's phase 3 clinical trials, were undertaken in a number of clinical situations, each with small differences in the study population and research design. The STEP 1 study, whose findings were published in the New England Journal of Medicine, found that individuals allocated to the pharmaceutical group lost an average of 14.9 per cent of their body weight after 68 weeks of therapy, compared to only 2.4 per cent for those assigned to the placebo group. The average weight reduction seen with present anti-obesity medicines is generally about 5% to 9%, while individuals engaged in lifestyle lose an average of 3% to 5%.

Nausea, diarrhoea, vomiting, and constipation are the most frequent adverse effects of Wegovy. The medicine also comes with a warning about the danger of a particular thyroid tumour, so it's not advised for anyone who has a personal or family history of medullary thyroid cancer or types 2 multiple endocrine neoplasias (a genetic condition associated with endocrine tumours). It's worth noting that tumours were only seen in animal studies and not in human trials.

How long can you take Wegovy?

Wegovy is one of six obesity medications presently authorized by the FDA for long-term use. As a result, it can be used indefinitely as long as it is effective for weight reduction and/or maintenance and does not cause unacceptable adverse effects. Exenatide was the first GLP-1 RA drug to get FDA approval in 2005; since then, numerous GLP-1 RAs have been authorized and have undertaken long-term studies proving either non-inferiority or superiority compared to placebo for severe adverse cardiovascular events including heart attacks and stroke. The SELECT study is a long-term cardiovascular outcomes trial for Wegovy, with the goal of determining the drug's impact on heart health.

Management of anti-obesity medications is changing.

Wegovy is the latest in a long series of medicines approved by the FDA for the treatment of obesity, beginning with phentermine in 1959. In the United States, phentermine, diethylpropion, benzphetamine, phendimetrazine, orlistat, phentermine/topiramate ER (Qsymia), bupropion/naltrexone (Contrave), liraglutide (Saxenda), setmelanotide (Imcivree), and recently semaglutide have all been authorized by the FDA (Wegovy). Setmelanotide, it should be noted, is only licensed for the treatment of obesity caused by uncommon hereditary disorders. Metformin, zonisamide, and other GLP-1 RAs are commonly used for treating diabetes.

Many cases of therapeutics failing to demonstrate sufficient safety data to warrant FDA approval, such as rimonabant (Acomplia), or adverse effects necessitating market withdrawal, such as lorcaserin (Belviq), sibutramine (Meridia), dexfenfluramine (Redux), fenfluramine (Pondimin), and the infamous combination medication Fen-phen. Unfortunately, the rocky anti-obesity drug landscape causes physicians to be hesitant to use the numerous safe and effective tools available today to treat obesity.

The cost of anti-obesity drugs

The high expense of some of the newer therapies, as well as the reluctance of many private and public insurance to pay for anti-obesity drugs, provide obstacles for those who do prescribe anti-obesity pharmacotherapy. Patients and their supporters may be successful in persuading their employers to include obesity management in their insurance coverage. Anti-obesity medicines, on the other hand, are now uninsured for individuals on Medicare or Medicaid.

Patients without insurance have three options: pay out of pocket for a lower-cost generic anti-obesity medication; take a medication designed to treat other medical conditions such as diabetes or seizures that may also help with weight loss; or, if their BMI and health status are severe enough to satisfy insurance requirements, opt for bariatric surgery, a much more expensive option.

The Treat and Reduce Obesity Act was originally presented in Congress in 2012 and was reintroduced in 2021 with the objective of modifying the Medicare Social Security Act to allow insurance coverage of obesity counselling services and FDA-approved anti-obesity medicines. The most difficult challenge in the obesity treatment landscape is persuading government agencies, employers, and insurers that drugs treating the most common chronic condition in the United States are truly worth paying for.

September 10, 2021

The cutest colorful press on nails designs ideas

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Chelsey is a creative nail artist with attractive bold nails put together with vibrant colours and catchy characters. These are the cutest press on nails to try while the weather is still fluctuating.

Nine things that make a group chat active.

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 Nine things that make a group chat active.

1. Learn to appreciate the posts of others, even if they are not your friends.

It gives them a sense of importance and encourages them to think about something more positive.

*2. In a group conversation, never run someone down on the platform.

You will drive them away and they will never express their objective viewpoints on topics.

*3. If you notice something from a member that you don't like, send them a private message.

Don't make a public assault on him/her on the platform.

*4. Never degrade or speak in a derogatory manner to members.

Roasted Tomato Spaghetti with Spinach & Chickpeas

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1/2 lb. spaghetti

1-pint cherry or grape tomatoes, sliced lengthwise seasoned with 1/2 tsp each kosher salt, pepper, oregano, garlic powder

1 tbsp olive oil for roasting

1 small yellow onion, finely chopped

2 tbsp olive oil

10 oz. mushrooms, very finely chopped

3/4 tsp each kosher salt, pepper, garlic powder

1 bell pepper, finely diced

3 cloves garlic, minced

1/2 cup reserved pasta cooking water

3 tbsp tomato paste

1/3 cup crushed tomatoes (canned)

1/2 15 oz. can chickpeas, drained and rinsed

1/4 cup fresh chopped parsley

2 cups (somewhat packed) baby spinach

2 tsp dried parsley

1/4 to 1/2 tsp red chilli flakes (to taste)

2 tsp lemon juice (optional)

1/4 to 1/3 cup coarsely chopped kalamata olives (to taste)

Rammed earth and sand on Hormuz island, Iran

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Have you ever visited this vibrant neighbourhood? It is located on Iran's Rainbow Island. Nader Khalili constructed this colourful house of earth domes, which is a beachfront housing complex.

Hormuz Island is located in the Persian Gulf, south of Iran, and is known as the "rainbow island" because of its colourful sand, which makes it a popular tourist destination. ZAV Architects developed a tiny town comprised of rainbow domes that overlap in unexpected combinations to provide houses and cultural activities such as laundry facilities, worship spaces, and a café in an effort to represent the colourful environment and terrain.

This multifunctional hamlet, known as Presence in Hormuz, is more than simply a bright and inviting refuge; it is the epitome of a paradigm change for the community. “The local people of the picturesque, touristy, and politically significant island suffer economically,” the architects add, “getting involved in criminal trafficking operations utilizing their boats.” This urban development initiative attempts to revitalize the local economy by using community people, both skilled and unskilled.


Say these encouraging words to yourself today.

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Our inner conversation has a significant role in our well-being and happiness. Having nice things to say to oneself might help you live a more fulfilling life. The way we speak to ourselves internally has a significant impact on how we live, make decisions, and feel. A negative internal conversation can have a significant influence on our mental and emotional well-being, thus it is critical that we do not be too hard on ourselves on a regular basis.


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