Plastics and personal care products contain a chemical that has been related to heart disease.
We are following this research.
Exposure to traffic noise is associated with an increased risk of dementia.
Could living near a busy road or train tracks increase your risk of developing dementia? According to a study published in The BMJ on Sept. 11, 2021, people who lived near noisy transportation routes for an extended period of time appeared to have an increased risk of dementia, specifically Alzheimer's disease, compared to those who lived in quieter areas.
A promising new approach to targeted therapy may expand treatment options for some women with early-stage breast cancer associated with specific genetic mutations. (Cancers in the early stages have not spread to distant organs or tissues.)
What does the BRCA gene do?
You may have heard of the BRCA (BReast CAncer) gene family, which includes the BRCA1 and BRCA2 genes. Normally, BRCA genes contribute to the repair of DNA (genetic code) damage that occurs on a regular basis in cells throughout the human body.BRCA mutations that are inherited are aberrant abnormalities in these genes that are handed down from parent to kid. When an individual carries a BRCA mutation, their body is unable to repair regular DNA damage to cells as easily. This cumulative damage to cells may contribute to the development of cancer. Having a BRCA1 or BRCA2 mutation — or both — increases a person's risk of developing breast, ovarian, prostate, or pancreatic cancer, as well as melanoma. Other gene alterations and other factors can also affect a person's risk of developing breast cancer.
In general, only about 3% to 5% of all women diagnosed with breast cancer have BRCA gene mutations. However, certain subgroups of people are more likely to have BRCA mutations, including those with triple-negative breast cancer (TNBC), Ashkenazi Jewish heritage, a significant family history of breast and/or ovarian cancer, and younger women with breast cancer.
Breast cancer types and inherited BRCA mutations
Breast cancers of specific types are frequently detected in women with BRCA gene mutations.Estrogen receptor-positive, HER2-negative breast cancer: Women with a BRCA2 mutation are more likely to develop estrogen receptor-positive, HER2-negative breast cancer — that is, cancer cells that are fuelled by estrogen but not by a protein called HER2 (human epidermal growth factor 2).
Women with a BRCA1 mutation are more likely to develop triple-negative breast cancer (ER-/PR-/HER2-) – cancer cells that are not fuelled by estrogen, progesterone, or HER2.
Understanding what causes various types of breast cancer to grow aids scientists in developing new treatments and physicians in selecting available therapies to delay or stop tumor growth. Frequently, this will require a combination of treatments.
A new treatment option for early-stage breast cancers associated with BRCA mutations
surgical procedure (a mastectomy or lumpectomy)
Chemotherapy (which may be administered before to or following surgery), radiation, and maybe a hormone-blocking medication called endocrine therapy.
They were randomly allocated to consume olaparib or a placebo (sugar tablets) twice daily for one year.
Olaparib is a member of a class of medications known as PARP inhibitors. PARP (poly adenosine diphosphate-ribose polymerase) is a typically occurring enzyme that aids in DNA repair. By inhibiting this enzyme in BRCA-mutated cancer cells, increasing DNA damage leads the cells to die.
The New England Journal of Medicine reported the study's findings. Women who got olaparib were less likely than those who received a placebo to have their breast cancer relapse or metastasis (spread to distant organs or tissues). After an average of two and a half years, slightly more than 85% of women who took olaparib were alive and had no recurrence of cancer or new second malignancy, compared to 77% of women given with placebo.
Additionally, the researchers calculated that after three years:
With olaparib, the probability of cancer not spreading to distant organs or tissues was roughly 88 percent, compared to 80 percent with placebo.The olaparib-treated group had a 92 percent chance of survival, while the placebo group had an 88 percent chance of survival.
Olaparib may cause a decrease in white blood cell count, a decrease in red blood cell count, and fatigue. These were extremely unlikely to develop.
Conclusion
Think zinc.
According to a new evaluation of the current research, over-the-counter zinc tablets may be one method to make cold and flu season a little easier. Of course, this isn't the first study to look into zinc as a COVID-19 antiviral treatment. However, the outcomes of the previous studies have been mixed at best: some studies show a slight benefit, while others show no benefit, and the research quality has been low. Zinc can also cause unpleasant side effects, such as stomach trouble, nausea, and, in some cases, a loss of sense of smell.
What did the research reveal?
According to the study, zinc can be used to prevent or treat colds and flu-like diseases. It was published in BMJ Open in November 2021. The researchers looked at over 1,300 prior studies before narrowing it down to 28 well-designed trials with over 5,000 study participants. What they discovered was as follows:
Cold and flu-like disease prevention:
Zinc pills or nasal spray zinc are linked to fewer upper respiratory infections when compared to placebo. The estimated effect was modest: for every 20 people who used zinc, about one illness was averted. The evidence supporting these conclusions is considered weak.
According to a few studies, the greatest preventive effects were seen in the reduction of severe symptoms including fever and flu-like illness. It's worth mentioning that the research didn't confirm whether or not the subjects were infected with the flu virus.
Zinc did not prevent colds in small investigations of people who were deliberately exposed to the virus.
Colds and flu-like illnesses can be treated using the following remedies:
Before stocking up on zinc, what else should you keep in mind?
Consequences.
Cost.
Deficiency in zinc.
A recent study demonstrates that the alternate biopsy procedure for the prostate is more complicated.
While coffee can provide a much-needed mental boost, new research says that you should limit yourself to five or six cups per day; beyond that amount may be detrimental to your brain. The researchers studied over 400,000 adults who consumed coffee on a daily basis (either caffeinated or decaffeinated). Daily consumption was classified into six categories ranging from one to two cups to more than six cups. Around 18,000 individuals had their brain volume evaluated using MRI. The research discovered that, when compared to moderate coffee drinkers (one to two daily cups), heavy coffee drinkers (more than six daily cups) had lower overall brain volume, particularly in the hippocampus, the region responsible for short- and long-term memory.
Additionally, heavy drinkers had a 53% increased probability of being diagnosed with dementia compared to light drinkers. The risk was similar whether individuals consumed caffeinated or decaffeinated coffee.
Mentally demanding jobs may help to lower the risk of dementia.
Are you employed in a mentally stimulating position? It may help lessen your risk of developing dementia later in life, according to a study published in The BMJ on Aug. 21, 2021. The researchers pooled data from several studies that explored the relationship between employment characteristics and chronic disease, disability, and death. They discovered that those with intellectually stimulating employment had a 23% lower risk of getting dementia than those with non-stimulating professions. Cognitively stimulating employment was classified as those that required individuals to make independent judgments and perform demanding tasks.
Journals
Increased consumption of the omega-3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) found in fatty fish such as salmon, herring, sardines, mackerel, and trout may help those with chronic migraines.
On average, 182 individuals had 16 headache days per month, with attacks lasting more than five hours, according to a clinical trial published in the July 3, 2021, issue of the British Medical Journal.
A brown or black streak beneath the nail, a bump or nodule beneath the nail, the darker skin around the nail, a nail that is lifting and pulling away from the nail bed, or a split down the middle of the nail are all signs of melanoma in and around the nails. Melanoma becomes more prevalent as people age, but it is highly treatable if detected early.
The research lasted six years and enrolled over 900,000 adults in the United States over the age of 30. The researchers examined the risk of lung cancer death in men and women who were current or past smokers or who had never smoked. When the study's findings were examined according to the tar rating of the cigarettes smoked, it was shown that the risk of lung cancer death was greatest for smokers of unfiltered cigarettes with a high tar content. There was no difference in the risk of lung cancer death among smokers of medium-, low-, and very low-tar cigarettes.
These findings are not entirely surprising to academics. According to a recent study, users of low-tar cigarettes compensate for the reduced tar content by altering their inhaling rhythm. Addicts can maintain their nicotine consumption (and exposure to carcinogens) with low-tar cigarettes by plugging ventilation pores in the filter, extending the draw duration, holding the puff longer and deeper, or smoking more cigarettes.
Cigarettes with less tar content were not produced until the 1960s and 1970s. Ultralight cigarettes are a more recent development. Many of the study's participants smoked medium- or high-tar cigarettes before the availability of low-tar cigarettes. As a result, the researchers were unable to assess the risk of lung cancer in people who only smoke low- or very-low-tar cigarettes. Despite this, the researchers feel that low-tar cigarettes have been available long enough and that the data suggests they pose the same danger as medium-tar cigarettes.
HOW TO QUIT SMOKING EFFECTIVELY.
Although quitting smoking is challenging, the advantages – decreased risk of lung cancer and heart disease, to mention a few – are well worth the effort at any age. To reduce your risk of illness, switching to low-tar or ultra-light cigarettes is not the answer. Numerous techniques exist to assist you in achieving your aim of stopping smoking. For further information, contact the American Lung Association, the American Heart Association, or the American Cancer Society. Consult your physician to determine which approach is best for you.
This research is still being monitored
Even moderate drinking may be detrimental to your brain, according to research published online by The BMJ on June 6, 2017. Researchers from the University of Oxford and University College London discovered that imbibers, even those who matched standards for moderate drinking, experienced a greater rate of cognitive loss and brain shrinkage than teetotalers.
The study tracked 550 men and women for 30 years, evaluating their brain structure and function to ascertain the long-term effects of alcohol usage on the mind. They discovered that the more people drank, the more atrophy happened in the hippocampus, a seahorse-shaped region in the brain involved in memory storage. Individuals who consumed 17 standard drinks or more of alcohol per week had the greatest risk. However, even moderate drinkers had an increased risk of cognitive impairments.
Protein is necessary for men to maintain muscle mass and strength as they age. According to research published online by JAMA Internal Medicine on July 13, 2020, the source of that protein may also influence how long people live. Scientists studied the diets of almost 400,000 people aged 50 and over who ate plant-based protein, red meat, and eggs. After then, they were tracked for more than 16 years. People who ate primarily plant protein rather than red meat or egg protein had a 13 per cent to 24 per cent decreased chance of dying from any cause.
If you've never had a urinary tract infection (UTI), take note: while the illnesses are uncommon in older males, they are frequent in older women, occurring in 10% of women aged 65 to 85. Up to a third of women who get a UTI will experience a recurrence within six months.
"E. coli bacteria which live in the intestines are responsible for roughly 80% of all recurrent UTIs and continue to generate antibiotic-resistant germ strains. The bacteria' ability to adhere to the urinary tract can make them extremely difficult to eliminate.
The causes of urinary tract infections
UTIs can develop in any part of the urinary system, including the kidneys, bladder, ureters (the tubes that carry urine from the kidneys to the bladder), or urethra (the tube that carries urine out of the body).
What is pollution?
Pollution is defined as anything that is introduced into the environment by humans that damages human health or ecosystems. There are different types of pollutions and they all affect human health. Air pollution, water pollution and soil pollution. These forms of pollution happen by the use of heavy metals, chemicals, gasses, germs, and even noise.
The combustion of fossil fuels (coal, gas, and oil), as well as wildfires, contribute to outdoor air pollution. These produce toxic fumes, smog (due to ground-level ozone), and soot (fine particles) that are dangerous to inhale. Fireplaces and home cookstoves that utilize gas, coal, or biomass fuels like wood or agricultural waste, which are sometimes used in low-income countries, are among the sources of indoor air pollution.
Since the passage of the Clean Air Act in 1970, air pollution in the United States has significantly decreased. However, certain air pollutant levels have risen in recent years, and air pollution continues to have severe national and global health impacts.
Different studies over the years have frequently repeatedly shown that increased outdoor air levels of fine particulate matter correspond to increased hospitalizations for chronic obstructive pulmonary disease exacerbation, stroke, diabetes, heart disease, pneumonia and other severe health issues. Whether it is a long term exposure or short-term exposure, they are all effective.
What is the impact of air pollution on your health?
This year, a study looked at worldwide models of pollution levels and risk assessments of the global population over the course of 14 years. It links fossil fuel consumption to over nine million premature deaths worldwide in 2018 — one in every five fatalities — with over 350,000 deaths in the United States. Heart attacks and strokes account for the majority of these fatalities.
This is an ongoing research
An infection, heart surgery, or unknown causes might cause the pericardium (the lining surrounding the heart) to become irritated. Pericarditis is a type of irritation that causes acute, stabbing pain in the centre of the chest. Although it normally goes away after four to six weeks, some people have many attacks.